The Effect of Castor Oil Packs on Measures of Liver Function.
Meridian Institute, December, 2002
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Abstract
Ten subjects (5 experimental and 5 control) participated in a test of
the effect of castor oil packs on measures of liver function: processing
of caffeine, aspirin, and acetaminophen. The members of the experimental
group used castor oil packs (flannel saturated with castor oil and warmed
by a heating pad) over the liver for 3 days, 1 hour per day. The members
of the control group used dry flannel warmed by a heating pad. Saliva and
urine samples were taken to be tested for liver function before and after
the 3-day castor oil pack exposure, and analyzed by the Great Smokies Diagnostic
Laboratory. There were no significant differences between the pre and post
samples for any of the measures of liver function, nor were there differences
between the experimental and control groups. Possible explanations include:
(1) no effect of castor oil packs on liver function, (2) low reliability
of some of the tests, (3) inadequate exposure to the castor oil packs for
an effect to be measured.
Introduction
The specific aim of this research project was to evaluate the effect
of castor oil packs over the right side of the abdomen on laboratory measures
designed to assess the liver's detoxification ability. It was intended
as a small trial to collect preliminary data.
Castor oil has a long tradition of use in folklore medicine and is probably
the best known Cayce remedy thanks to the work of Drs. Bill and Gladys
McGarey. Historically, there is evidence that castor oil has been used
medicinally since ancient Egypt. It was known to the Greeks as Kiki
and to the Romans as Palma Christi. Beginning in the 17th
century, castor oil was taken internally for its effect as an "irritant"
or "stimulant" to cleanse the digestive tract. It has been shown to have
a number of direct effects on the gastrointestinal tract when taken by
mouth that usually result in producing a diarrhea. This includes the stimulation
of endogenous prostaglandin synthesis by the bowel. In the early 20th
century, Edgar Cayce recommended castor oil packs as an external application
over the right side of the abdomen for a variety of conditions. These were
intended to help increase eliminations, stimulate the liver and gallbladder,
and dissolve adhesions (McGarey, 1993).
In 1980, the active component of castor oil was identified as ricinoleic
acid, a C18, monounsaturated (at C9-10), monohydroxylated (at C12), aliphatic
fatty acid (Luderer et al, 1980). Castor oil is generally about 90% ricinoleic
acid with minor components of oleic and linoleic acids (Gaginella and Phillips,
1975).
Methods
Ten adult subjects were recruited (3 male, 7 female). None had been
diagnosed with liver disease. All had some previous experience using castor
oil packs. In addition, during the consent process, they were informed
that review of the literature and search of the "material safety data sheet"
on the Internet indicates that castor oil is used in a number of dermatological
products and is not expected to present any health hazard from skin exposure.
The only cited risk is the possibility of mild skin irritation and redness.
They were also informed that the heating pads may produce a skin burn if
used incorrectly.
The subjects were randomized into two groups of five. The experimental
group used castor oil packs over the right side of the abdomen with heat
(produced by a standard heating pad) for 1 hour for three straight days.
The control group used heat alone (over dry flannel), also for 1 hour for
three straight days. No attempt was made to blind the subjects or experimenters
regarding group assignment, since it is difficult to come up with a plausible
placebo substitute for castor oil.
Pre and post assessment of liver function using the Great Smokies Diagnostic
Laboratory's "detoxification profile" was performed the day before application
of the first pack and heat or the heat alone, and again the day after the
three day series. This profile measures the livers response to functional
challenges with caffeine, acetaminophen, and salicylate. The challenge
dose includes 650 mg aspirin, 650 mg acetaminophen, and 200 mg of caffeine.
Twelve hours before beginning the testing, following instructions provided
with the test kits, subjects were asked to stop taking any medications
that contain acetaminophen or aspirin and to avoid alcohol and substances
containing caffeine (coffee, all soft drinks, tea, hot cocoa, chocolate,
and certain medications). The day of the testing, they were asked to avoid
fruit (particularly raisins and prunes), licorice and peppermint, candies,
nuts, and seeds.
The procedure for the detoxification profile involved subjects taking
one NoDoz caplet in the morning with water. Two hours after taking the
caplet, a sample of saliva was collected. Six hours after obtaining the
first sample, a second saliva sample was collected. That evening, two Bayer
aspirin and two acetaminophen tablets were taken with water. For the next
ten hours, all urine was collected and a sample sent for analysis. During
these ten hours, the subjects were not to eat or drink anything but water.
Half the subjects applied castor oil packs over the right sides of their
abdomens. This involved soaking wool flannel with warmed castor oil and
placing it over the liver, gallbladder, and ascending colon region. This
was covered with plastic and then a heating pad set on the "high" setting.
This was left in place for one hour. After removing the pack, the skin
was washed off with a solution of baking soda and warm water (one teaspoon
to one pint of water).
Results
Table 1 shows the means, standard deviations and p values for the associated
t-tests for the five measures of liver function, comparing pre and post
measures for the experimental and control groups separately. Table 2 shows
mean changes from pre to post, with t-tests comparing the experimental
and control groups. None of the t-tests was significant at the 0.05 level.
Since there were no differences between the experimental and control
groups, the scores were pooled to examine test/retest reliability. Table
3 gives the test/retest correlation coefficients.
Table 4 is a comparison of the means and ranges of the 5 tests with
the norms provided by the Great Smokies Diagnostic Laboratory. The caffeine
test stands out in being skewed in our sample toward the low end of the
normative range, as does the aspirin test (salicyluric acid) with a mean
for our sample above the high end of the normative range. Acetaminophen
glucuronide is also skewed toward the low end of the normative range.
Discussion
The results provide no evidence for the hypothesis that castor oil packs
affect liver function as measured by these tests. Furthermore, even though
the sample size is small, roughly equal numbers of subjects got slightly
higher scores or slightly lower scores in both the experimental and the
control groups, so there is no suggestion that a larger sample might give
statistically significant results.
The results do provide some normative data for our sample on these tests,
both in terms of normative distributions and reliability. None of the subjects
is known to be suffering from liver disease, so it is reasonable that the
average scores and the distribution of scores would be close to the norms.
For the caffeine test, however, almost all the scores were at the low end
of the normal range, whereas for the aspirin test the scores were mostly
at the high end of the range. One of the acetaminophen tests also had a
mean for our sample at the high end of the range. This suggests that, for
these three tests, our sample is very different from the population on
which the tests were normed. For the other tests, the scores were distributed
across the range, with the mean roughly in the middle.
The test-retest reliability of the salicyluric acid, acetaminophen sulfate,
acetaminophen mercapturate, and acetaminophen glucuronide tests is reasonable
(from 0.78 to 0.89), but the reliability for the caffeine test is very
low (0.21). This low reliability, combined with the preponderance of scores
on the low end of the norms provided by the Great Smokies Diagnostic Laboratory,
suggests that the caffeine test as it is currently performed and interpreted
may not provide useful information (or that our sample is very poor and
variable in its ability to metabolize caffeine).
If castor oil packs do, in fact, affect the processing of these substances,
there are several possible reasons that the results showed no effect.
First, it is possible that the effect is smaller than the inherent variability
in the tests. This is certainly a possibility for the caffeine test, which
appeared to have low reliability. But since these tests are supposed to
be more sensitive to small variations in liver function when compared to
more standard tests such as SGPT, these results are not encouraging, and
it would take a very large sample to test this hypothesis.
Second, the effects, particularly in a short exposure to the packs as
in this protocol, might be very short-lived. Thus, by the day after
the third pack when the post measurement was done, the liver might have
returned to its baseline level of functioning. A better method might be
to do the test during the third day of pack use.
Third, it is possible that the 3-pack exposure was not sufficient by
itself to stimulate the liver to a measurable degree. In a modified protocol,
closer to Cayce's typical recommendations, the subjects might use the castor
oil packs for four 3-pack cycles over a 1-month period, or even longer,
with pre and post measurements.
Fourth, it is possible that, within normal range of liver function,
castor oil packs have no effect; an effect might only appear with a seriously
low-functioning liver. Thus, another strategy might be to repeat the protocol
with people diagnosed with liver disease, perhaps who already had evidence
from more standard tests of liver function. Pre and post standard tests
could be compared with these less conventional tests.
Finally, it may be worth backing up to ask the question: is there any
evidence that the castor oil crosses the barrier of the skin into the bloodstream?
A urine test for castor oil metabolites following use of castor oil packs
could establish this (e.g, the tests used by Hagenfeldt et al., 1986).
References
Gaginella TS, Phillips SF. Ricinoleic acid: current view of an ancient
oil. Digestive Diseases 1975;20:1171-1177
Hagenfeldt L, Blomquist L, Midtvedt T. Epoxydicarboxylic aciduria resulting
from the ingestion of castor oil. Clinica Chimica Acta 1986;161:157-163.
Luderer, JR et al. Mechanism of action of castor oil: a biochemical
link to the prostaglandins. Advances in Prostaglandin and Thromboxane Research,
Vol. 8., ed. by B. Samuelson, 1980, pgs. 1633-1635.
McGarey WA. The Oil that Heals. A.R.E. Press, Va. Beach, VA,
1993.
Table 1. T-test comparison of pre and post measures of liver function
(n = 10).
Experimental |
|
|
|
|
|
|
Mean Pre |
SD |
Mean Post |
SD |
p (2-tailed) |
Caffeine |
0.70 |
0.35 |
0.70 |
0.42 |
1.00 |
Salicyluric Acid |
67.0 |
6.9 |
69.2 |
11.6 |
0.70 |
Acetaminophen sulfate |
28.2 |
10.4 |
29.6 |
5.0 |
0.60 |
Acetaminophen mercapturate |
10.8 |
3.4 |
11.4 |
1.7 |
0.51 |
Acetaminophen glucuronide |
33.6 |
6.4 |
38.2 |
11.0 |
0.13 |
Control |
|
|
|
|
|
|
Mean Pre |
SD |
Mean Post |
SD |
p (2-tailed) |
Caffeine |
0.54 |
0.13 |
0.74 |
0.62 |
0.58 |
Salicyluric Acid |
44.2 |
14.2 |
41.6 |
15.4 |
0.52 |
Acetaminophen sulfate |
24.6 |
11.8 |
22.4 |
7.4 |
0.49 |
Acetaminophen mercapturate |
5.3 |
2.8 |
7.7 |
2.6 |
0.06 |
Acetaminophen glucuronide |
30.8 |
11.1 |
29.2 |
11.4 |
0.68 |
Table 2. T-test comparison of experimental and control groups on changes
in measures of liver function (n = 10).
|
Mean Expt |
SD |
Mean Ctrl |
SD |
p (2-tailed) |
Caffeine |
0.0 |
0.2 |
0.2 |
0.7 |
0.57 |
Salicyluric Acid |
2.2 |
11.9 |
-2.6 |
8.2 |
0.48 |
Acetaminophen sulfate |
1.4 |
5.5 |
-2.2 |
6.4 |
0.37 |
Acetaminophen mercapturate |
0.6 |
1.8 |
2.4 |
2.1 |
0.18 |
Acetaminophen glucuronide |
4.6 |
5.4 |
-1.6 |
8.2 |
0.19 |
Table 3. Test-retest reliability of measures of liver function as shown
by correlation coefficients (n = 10).
|
r |
p |
Caffeine |
0.21 |
0.57 |
Salicyluric Acid |
0.86 |
0.001 |
Acetaminophen sulfate |
0.85 |
0.002 |
Acetaminophen mercapturate |
0.89 |
0.001 |
Acetaminophen glucuronide |
0.78 |
0.008 |
Table 4. Comparison of means and ranges for this study and for the
norms provided by Great Smokies Diagnostic Laboratory (n = 10).
|
10 Subjects |
Norms |
|
Mean |
Range |
Mean |
Range |
Caffeine |
0.6 |
0 - 1.7 |
1.05 |
0.5 - 1.6 |
Salicyluric Acid |
55.2 |
22 - 87 |
41.5 |
30 - 53 |
Acetaminophen sulfate |
24.8 |
9 - 45 |
26 |
16 - 36 |
Acetaminophen mercapturate |
9.0 |
2.5 - 14.2 |
8.5 |
5.6 - 11.4 |
Acetaminophen glucuronide |
28.9 |
13 - 49 |
41.5 |
27 - 56 |
|